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Open letter in support of Chuan-Guo Xiao, M.D. from the International Academic Community (1650 查看)

November 08, 2012 09:47PM
Open letter in support of Chuan-Guo Xiao, M.D. from the International Academic Community

September 29, 2010


To all,

We have all had the pleasure of knowing Dr. Chuan-Guo Xiao for many years. He is an internationally respected surgeon-scientist who has made major advances in the development of neuroregeneration to restore voiding and bowel function. Dr. Xiao performed groundbreaking animal research in the United States, demonstrating that a motor nerve that innervates the leg can be used to reinnervate the bladder and bowel. This reinnervation allows for development of a reflex to initiate bladder function. The results of his studies were published in peer-reviewed journals and other scientists have replicated Xiao’s findings confirming these results.

Dr. Xiao eventually took the courageous step of moving from animal research to human studies and began performing the rerouting procedure on patients with spinal cord injury and spina bifida in China. Neurogenic bladder is life threatening in China due to a lack of both antimuscarinics and intermittent catheterization, and lessening the complications of neurogenic bladder would be considered a lifesaving success. Patients with neurogenic bladder and bowel suffer greatly and endure a host of issues such as urinary retention, incontinence, recurrent infections, renal insufficiency, fecal incontinence, constipation, and poor quality of life. For a procedure as complicated as nerve rerouting requiring nerve regeneration, one cannot expect normalization of bladder and bowel function to be the definition of success. What is important is that the benefits outweigh the risks of the procedure.

Dr. Xiao published his clinical results in peer-reviewed journals and was twice honored by the Jack Lapides Essay Contest, one of the most respected international awards given to scientists who make major contributions to the field of neurourology. In 2008, he was named the Kelm Hjalmas Memorial Lecturer from the International Children’s Continence Society for his scientific achievements. Many of us have traveled to China to examine patients treated by Dr. Xiao and/or have been trained by him in the nerve rerouting surgery he invented. Dr. Xiao is a very skilled surgeon who is passionate about patient care and works tirelessly to train physicians around the world in performing his nerve rerouting procedure.

In the United States, an independent and very rigorous pilot research trial was performed to test the safety and efficacy of this procedure. The one-year results were recently published in the Journal of Urology. At the 12-month follow-up visit, a cutaneous to bladder reflex was found in 7 of 9 spina bifida patients, confirming that rerouting does occur. This finding by itself is remarkable and Dr. Xiao should be commended. In addition, a number of patients demonstrated improvement in bladder and bowel function, which has continued to improve with longer patient follow-up. The 36-month results are currently being analyzed and will be reported in the near future. The pilot data was supportive of Dr. Xiao’s procedure, and now an NIH sponsored clinical trial is being conducted to further study lumbar to sacral nerve rerouting in spina bifida patients. In addition, similar procedures have been done worldwide, with Dr. Xiao helping to mentor the surgeons at each site.

The Chinese people and government should be proud of Dr. Xiao for his dedication to his patients, his scientific achievements, and his willingness to train doctors around the world how to perform his surgery. The International scientific community was shocked to hear of Dr. Xiao’s arrest. Those of us who know Dr. Xiao well find it difficult to believe that he is involved in these attacks.

Dr. Xiao is a compassionate man who is respected worldwide for his integrity and his innovative scientific contributions to society. We implore the Chinese government and authorities to treat Dr. Xiao fairly and to protect his human rights as these charges are investigated. Please strongly consider Dr. Xiao’s scientific and humanitarian contributions to the world as facts are gathered in this case.

Sincerely,

Kenneth M. Peters, MD Professor and Chairman of Urology Beaumont Hospital Royal Oak, Michigan USA

Jack S. Elder, M.D. Chief of Urology, Henry Ford Health System Associate Director, Vattikuti Urology Institute Department of Urology, Children's Hospital of Michigan Detroit, MI USA

Edwin A. Smith M.D. Assistant Clinical Professor of Urology Emory University School of Medicine Atlanta, Georgia USA

Kevin M. Feber, MD, FAAP Beaumont Children's Hospital Royal Oak, MI USA

Ananias C. Diokno, M.D., F.A.C.S. Executive Vice President & CMO Beaumont Hospital Royal Oak, Michigan 48073 USA

Juan José de Benito Urologist Hospital Nacional de Clínicas Córdoba, Argentina.

William E. Nantau B.Sc., CNIM Clinical Manager Clinical Neurophysiology Department Beaumont Hospital Royal Oak, MI USA

Evan J Kass MD,FACS,FAAP Chief, Division of Pediatric Urology Beaumont Childrens Hospital Professor of Urology, Oakland University-William Beaumont School of Medicine USA

Jacques Corcos MD. Professor of Urology, McGill University General Secretary of the International Continence Society Jewish General hospital 3755 Cote Ste-Catherine Montreal, Quebec, Canada H3T 1E2

Jose Gonzalez, M.D. Department of Urology Beaumont Hospital Royal Oak, Michigan USA

Christopher Payne, MD Associate Professor of Urology Stanford University Medical School Stanford, CA 94305-5118 USA

Kenneth I. Glassberg, MD Director, Division of Pediatric Urology Morgan Stanley Children's Hospital of New York-Presbyterian Professor of Urology, Columbia University College of Physicians and Surgeons 3959 Broadway, CHN 1118 NY USA

Earl Y. Cheng, MD Associate Professor of Urology Children’s Memorial Hospital Chicago, Illinois USA

Darius J. Bagli, MDCM Professor of Surgery Senior Associate Scientist Director of Urology Research Divisions of Urology and Developmental & Stem Cell Biology The Hospital For Sick Children Institute of Medical Science University of Toronto

Henri B. LOTTMANN, MD, FEBU, FEBPS, FRCS(england) FEBPU Paediatric urology unit Hopital Necker-Enfants-Malades 149, rue de Sèvres 75015 Paris, France

Dr. Amrish Vaidya MS. MCh. Consultant Paediatric Surgeon, Kokilaben Dhirubhai Ambani Hospital, 4 Bungalows, Andheri W, Mumbai, India

Marc Cendron, MD Associate Professor in Urology Harvard Medical School Children’s Hospital Boston Boston, MA USA

Stuart B. Bauer, MD Associate Director, Neurourology Professor of Urology Harvard Medical School Children’s Hospital Boston Boston, MA USA

Edmond T. Gonzales, Jr., MD Professor of Urology Baylor College of Medicine Houston TX USA

Richard Macchia, MD FACS SUNY Distinguished Teaching Professor Cleveland Clinic, Florida Benjamin Girdler, MD Urology Center of the Rockies Fort Collins, Colorado USA

William C. de Groat, Ph.D. Professor of Pharmacology University of Pittsburgh Pittsburgh, PA USA

Michael R. Ruggieri, Sr., Ph.D. Director of Urologic Research Temple University School of Medicine Philadelphia, PA USA

Stanley J Kogan MD Chief, Pediatric Urology Children's Hospital at Montefiore Bronx NY USA

Anthony Caldamone, MD University Urologic Associates, Inc. 2 Dudley St Ste 185 Providence, RI 02905 USA

Yves Homsy MD, FRCSC, FAAP Clinical Professor of Urological Surgery and Pediatrics University of South Florida Children's Urology Group 5507 E. Longboat Blvd Tampa FL 33615 USA

Dr. Enrique Turina Professor of urology of the National University of Buenos Aires Chief of section Urology of Instituto de Rehabilitación Government of Buenos Aires, Argentina.

Dr. Angel Ozón Urologist of the Instituto de Rehabilitación of Buenos Aires

Dr. Daniel Ekizian Urologist of Instituto de Rehabilitación.

Professor Dr. med. Karl-Dietrich Sievert Vice Chair Prof. of Urology, Director - Uro-oncology, Neurourology, Incontinence, & Reconstructive Urology Department of Urology University of Tuebingen D72076 Tuebingen, Germany

Holly Gilmer, MD Chief of Pediatric Neurosurgery Beaumont Hospital Royal Oak, Michigan USA

Yegappan Lakshmanan, MD Chief, Pediatric Urology Children’s Hospital of Michigan Detroit, MI USA
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